Epitalon 50 mg
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Epitalon 50 mg

Epitalon (Epithalon) · Tetrapeptide

€109.95per unit
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Product details

Epitalon 50 mg

Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, commonly abbreviated AEDG. The free-peptide molecular formula is C14H22N4O9 and its average molecular mass is 390.35 g/mol. It has a free N-terminal alanine amine and three free carboxyl groups: the glutamate side chain, the aspartate side chain and the C-terminal glycine. It has no disulfide bridge, cyclisation, lipid conjugation or PEG conjugation.

References

  1. 1Research use

    Supplied for laboratory research only. Not for human or veterinary use, consumption or self-administration.

  2. 2Receipt & transport

    Inspect the vial and seal on arrival. Contact us about damage or an unexpected condition. Transport alone does not establish chemical stability or suitability for an experiment.

  3. 3Storage

    Follow the instructions supplied with the material and your laboratory’s validated procedure. Keep the vial sealed and protect it from moisture and light. Confirm product-specific temperature and shelf-life information before use.

  4. 4Laboratory solutions

    Solvent, pH, concentration and storage conditions depend on the material and assay. Use a validated laboratory protocol; a general mixing calculator does not establish compatibility, sterility or solution shelf life.

Documentation

No independent report is currently linked to this new strength.

Published papers are not certificates for this vial. Ask for the applicable analytical documentation; reports for another product or strength do not verify this listing.

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Frequently asked questions

What is supplied?

1 vial · 50 mg · Lyophilised powder. The stated milligrams describe total vial content, not a dose or the concentration of a prepared solution.

Documentation

No independent report is currently linked to this new strength. Published papers are not certificates for this vial. Ask for the applicable analytical documentation; reports for another product or strength do not verify this listing.

Can I order this strength now?

Yes. Select the quantity, add this vial to your cart or choose Buy now. Other vial strengths are listed separately.

How should I read the research?

The cited studies describe particular experimental materials and conditions. They do not test this supplied vial or establish its suitability for human or veterinary use.

Related research reading
Research & references

Description of Epitalon

Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, commonly abbreviated AEDG. The free-peptide molecular formula is C14H22N4O9 and its average molecular mass is 390.35 g/mol. It has a free N-terminal alanine amine and three free carboxyl groups: the glutamate side chain, the aspartate side chain and the C-terminal glycine. It has no disulfide bridge, cyclisation, lipid conjugation or PEG conjugation.

The peptide was designed from the amino-acid composition of Epithalamin, a peptide preparation extracted from bovine pineal gland. Epitalon is therefore a defined four-residue peptide; Epithalamin is a tissue-extract preparation. The two materials are not interchangeable. Older work on the extract should not be presented as a study of the synthetic AEDG molecule.

Registry entries for the synthetic tetrapeptide must be distinguished from database entries also associated with the extract. A name or registry number should therefore be matched to an actual structural and analytical specification. The molecular formula and sequence given here describe the literature molecule; they are not a measurement of the supplied 50 mg vial or a claim about its counter-ion.

Overview of Published Research

The references below cover several different experimental settings: human somatic-cell cultures, mouse studies and other laboratory models. They must be read according to the material and endpoint actually studied. The defined AEDG peptide, a tissue extract and a supplied catalogue vial are three separate evidential questions. This 50 mg listing does not turn cell-culture or animal findings into evidence of human longevity or an anti-ageing treatment.

Al-Dulaimi and colleagues (2025) studied normal and cancer cell lines. They reported telomerase-related telomere changes in normal cells and alternative lengthening of telomeres (ALT) in cancer cells. These are cell-model findings, not evidence of a longer human lifespan or a clinical effect of this vial.

References

  1. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592. doi: 10.1023/a:1025493705728 · PubMed
  2. Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bulletin of Experimental Biology and Medicine. 2004;137(5):503-506. doi: 10.1023/b:bebm.0000038164.49947.8c · PubMed
  3. Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NYu, Semenchenko AV, Yashin AI. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. doi: 10.1023/a:1025114230714 · PubMed
  4. Anisimov VN, Khavinson VKH, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer. 2002;101(1):7-10. doi: 10.1002/ijc.10570 · PubMed
  5. Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology. Bulletin of Experimental Biology and Medicine. 2002;133(3):293-299. doi: 10.1023/a:1015859322630 · PubMed
  6. Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism. Molecules. 2020;25(3):609. doi: 10.3390/molecules25030609 · PubMed
  7. Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging (Albany NY). 2022;14(7):3191-3202. doi: 10.18632/aging.204007 · PubMed
  8. Araj SK, Brzezik J, Madra-Gackowska K, Szeleszczuk L. Overview of Epitalon: highly bioactive pineal tetrapeptide with promising properties. International Journal of Molecular Sciences. 2025;26(6):2691. doi: 10.3390/ijms26062691 · PubMed
  9. Ullah S, Haider Z, Perera CD, Lee SH, Idrees M, Park S, Kong IK. Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development. Life Sciences. 2025;362:123381. doi: 10.1016/j.lfs.2025.123381 · PubMed
  10. Vanhee C, Moens G, Van Hoeck E, Deconinck E, De Beer JO. Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Drug Testing and Analysis. 2015;7(3):259-264. doi: 10.1002/dta.1771 · PubMed
  11. Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025. doi: 10.1007/s10522-025-10315-x · PubMed
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