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Synthetic tetrapeptide, Ala-Glu-Asp-Gly, epithalamin-derived pineal peptide
For laboratory research only. Not for human or animal use.
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Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, commonly abbreviated AEDG. The molecular formula is C14H22N4O9, the average mass is 390.35 g/mol and the calculated monoisotopic mass is 390.139 (PubChem CID 219042; InChIKey HGHOBRRUMWJWCU-FXQIFTODSA-N). The molecule carries a free N-terminal alanine amine and three free carboxyl groups: the glutamate side chain, the aspartate side chain, and the C-terminal glycine. That arrangement leaves it anionic at neutral pH and water-soluble. All three stereocentres are L, and the glutamate is joined through its alpha-carboxyl rather than the side chain. There is no disulfide bridge, no cyclisation and no lipid or PEG conjugation, so the peptide is assembled by routine solid-phase synthesis and is short enough to be sequenced directly by tandem mass spectrometry.
All presented information is based on scientific publications which can be found at the end of product description below.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, ect.
Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.
Upon receiving the lyophilized peptide, store at 4 °C or colder and away from bright light. Lyophilized peptides are stable at room temperature for weeks, but for longer-term storage, it is safer to store at -20 °C or colder. Exposure to moisture will greatly decrease long-term stability of lyophilized peptides. Before using the peptide, remove from cold storage and allow the peptide to equilibrate to room temperature before removing the lid of the container, in order to reduce the uptake of moisture that is present in the surrounding atmosphere.
The shelf life of peptide solutions is limited. Freezing the aliquots will prolong the storage life of the peptide. What is globally accepted for peptides in solution is that they are generally stable for 3 or more weeks at +4°C and for 3-4 months at -20°C. Avoid repeated freeze-thaw cycles, as this can degrade the peptides.
Used solely for in vitro experiments and cannot be:
No. Epitalon has an average molecular mass of 390.35 g/mol for the formula C14H22N4O9 in the molecular specification. The 10 mg is the stated material mass in this vial, not a molecular weight or a solution concentration.
No. Epitalon is the defined synthetic tetrapeptide Ala-Glu-Asp-Gly (AEDG), also called Epithalon in publications. Epithalamin is a pineal tissue-extract preparation. The original cell-culture study concerns the synthetic peptide; findings about the extract should not be attributed to this vial.
No. The 2003 study reported telomerase activity and telomere elongation in cultured human fetal fibroblasts. A 2004 follow-up reported additional divisions in cultured cells. These were laboratory studies, not trials demonstrating longer life, improved sleep or a safe dose in people. This vial is supplied for laboratory research only.
No independent Epitalon 10 mg report is currently published in our certificate library. A stated purity target is a specification, not a measured result. Ask about product documentation if your laboratory requires an independent result before ordering.
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Neutral reference material and handling tools from across the site. Research use only.
Compounds studied in cellular energy and longevity research.
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Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, commonly abbreviated AEDG. The molecular formula is C14H22N4O9, the average mass is 390.35 g/mol and the calculated monoisotopic mass is 390.139 (PubChem CID 219042; InChIKey HGHOBRRUMWJWCU-FXQIFTODSA-N). The molecule carries a free N-terminal alanine amine and three free carboxyl groups: the glutamate side chain, the aspartate side chain, and the C-terminal glycine. That arrangement leaves it anionic at neutral pH and water-soluble. All three stereocentres are L, and the glutamate is joined through its alpha-carboxyl rather than the side chain. There is no disulfide bridge, no cyclisation and no lipid or PEG conjugation, so the peptide is assembled by routine solid-phase synthesis and is short enough to be sequenced directly by tandem mass spectrometry.
The peptide was designed at the St Petersburg Institute of Bioregulation and Gerontology, where Vladimir Khavinson's group built it from the amino-acid composition of Epithalamin, a peptide preparation extracted from bovine pineal gland. Epitalon is therefore a defined four-residue peptide derived from an undefined tissue extract, and the two materials are not interchangeable. Older literature written about "epithalamin" describes the bovine extract; papers on "Epitalon", "Epithalon", "Epithalone" or "AEDG peptide" describe the synthetic tetrapeptide. The distinction matters when reading the record, because a substantial share of the human data attributed to this compound in secondary sources was generated with the extract rather than with AEDG.
The registry number for the synthetic tetrapeptide is CAS 307297-39-8 and the FDA UNII is O65P17785G; both describe the free peptide, with no counterion in the registered structure. PubChem also carries 64082-79-7 in its CAS section for the same record, a number indexed in ChemIDplus under the name Epithalamin, the bovine pineal extract. Databases and vendor catalogues do not agree on which material that second number properly belongs to, so a listing quoting it should not be assumed to describe the defined tetrapeptide. Supplied here as a white lyophilised powder specified at >=99% purity, with the certificate of analysis as the controlling record for peptide content, purity and counterion. A 2025 review in International Journal of Molecular Sciences (Araj et al.) observes that, set against the volume of biological work on this peptide, physico-chemical and structural investigation of the molecule itself remains quite limited.
Epitalon is the defined synthetic tetrapeptide Ala-Glu-Asp-Gly (AEDG). This catalogue entry specifies a 10 mg vial. When comparing publications, distinguish the defined tetrapeptide from Epithalamin, the tissue-extract preparation discussed in some older literature. The two materials should not be treated as interchangeable.
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