MOTS-c

Name: MOTS-c
Brand: PowerfullyPeptides
SKU: mots-c
Price: 49.00 EUR
Availability: OutOfStock

MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA region of mitochondrial DNA, studied for its role in metabolic homeostasis, insulin sensitivity and exercise physiology. Supplied lyophilised for laboratory research use only.

Read the full research profile →

How it works · what studies report · scientific references

Sold out

≥99% purity target · lot-tracked

Select size

10 mg vial

€49.0010 mg vial

Ships from IrelandTracked

Dispatched in 1–2 working daysTracked, EU dispatch

Lost in transit?Replacement first

Real supportWhatsApp & email

Plain outer packaging, no product names or branding on the parcel. Questions? WhatsApp us

Currently sold out — join the Insiders list below for the restock notice.

Why does the vial look empty?

That’s normal. The peptide is supplied lyophilised (freeze-dried) — often a thin film or a few milligrams at the base of the vial, easy to mistake for empty. It’s all there; reconstitute with bacteriostatic water before use.

Research handling note

Reconstitute with bacteriostatic water and store the lyophilised vial at −20 °C until use; once reconstituted, refrigerate and use within the documented window. For laboratory research purposes only — not for human consumption, diagnostic, or therapeutic use. Need to work out your dilution? Use the reconstitution calculator →

Metabolic Research

MOTS-c — research profile

For research purposes only — not for human consumption

MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a short peptide encoded within mitochondrial DNA — one of a small family of mitochondrial-derived peptides. It is studied as a signalling molecule that links mitochondrial status to whole-cell and whole-organism metabolism.

Research reports that under metabolic stress MOTS-c translocates to the nucleus and helps regulate gene expression, and that it activates the AMPK energy-sensing pathway — placing it at the centre of interest in metabolic-homeostasis and exercise-physiology models.

How it’s studied

AMPK activation: engagement of the master cellular energy-sensing pathway.
Insulin sensitivity: glucose-handling and metabolic-flexibility models.
Nuclear signalling: stress-responsive gene regulation.
Exercise physiology: exercise-induced expression and muscle homeostasis.

Areas under investigation

Area	Reported research focus
Metabolic homeostasis	AMPK-linked glucose and lipid handling.
Insulin resistance	Metabolic-stress and obesity models.
Physical performance	Exercise-induced regulation of muscle function.

References

Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–454.
Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical performance and muscle homeostasis. Nat Commun. 2021;12:470.

Specifications

Specification	Detail
Product	MOTS-c
Format	Lyophilised vial
Fill	10 mg per vial
Molecular formula	C101H152N28O22S2
Purity	Specified to a 99%+ purity target — per-batch documentation will be published once independent lab testing completes
Price	€49.00
Availability	Currently sold out — restock in progress. Join the Insiders list for the restock notice.
Supplied for	Laboratory research use only — not for human consumption, diagnostic or therapeutic use

Verifiability

Batch Testing & COA

Every production batch is sent for independent, third-party analysis at Janoshik Analytical. When results return, the full Certificate of Analysis for the exact batch you receive is published here and in our COA library, carrying its SHA-256 checksum and the lot number printed on your vial, so you can confirm the document is genuine and untampered. We publish every certificate, including any that fail.

How to verify a COA and its SHA-256 checksum →