Semax

Name: Semax
Brand: PowerfullyPeptides
SKU: semax
Availability: InStock

Semax is a synthetic peptide based on the ACTH(4-10) fragment, studied as a nootropic and neuroprotective research compound. Supplied for laboratory research use only.

Read the full research profile →

How it works · what studies report · scientific references

In stock

≥99% purity target · lot-tracked

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Vial

Nasal spray

€30.00Vial

Ships from IrelandTracked, inside the EU

Dispatched in 1–2 working daysTracked, EU dispatch

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Why does the vial look empty?

That’s normal. The peptide is supplied lyophilised (freeze-dried) — often a thin film or a few milligrams at the base of the vial, easy to mistake for empty. It’s all there; reconstitute with bacteriostatic water before use.

Research handling note

Reconstitute with bacteriostatic water and store the lyophilised vial at −20 °C until use; once reconstituted, refrigerate and use within the documented window. For laboratory research purposes only — not for human consumption, diagnostic, or therapeutic use. Need to work out your dilution? Use the reconstitution calculator →

Neuropeptide Research

Semax — research profile

For research purposes only — not for human consumption

Semax is a synthetic heptapeptide derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH), modified for metabolic stability. Developed in Russia, it is studied for nootropic, neuroprotective and neurorestorative activity without the hormonal action of full-length ACTH.

Research reports rapid increases in brain-derived neurotrophic factor (BDNF) and its trkB receptor signalling, modulation of the melanocortin system, and effects on dopaminergic and serotonergic transmission in cell and animal models.

How it’s studied

BDNF / trkB signalling: up-regulation of neurotrophin expression in the hippocampus.
Melanocortin pathway: ACTH-fragment activity without steroidogenesis.
Neuroprotection: ischaemia and oxidative-stress models.
Cognition: attention, learning and memory tasks.

Areas under investigation

Area	Reported research focus
Focus & cognition	Attention and learning pathways in research models.
Neuroprotection	Ischaemic and hypoxic injury models.
Neuroplasticity	BDNF and NGF expression.

References

Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54–60.

Specifications

Specification	Detail
Product	Semax
Format	Lyophilised vial or nasal spray
Fill	5 mg
Molecular formula	C37H51N9O10S
Purity	Specified to a 99%+ purity target — per-batch documentation will be published once independent lab testing completes
Price	€30.00 (vial) · €35.00 (nasal spray)
Availability	In stock — dispatched from Ireland within 1–2 working days, tracked
Supplied for	Laboratory research use only — not for human consumption, diagnostic or therapeutic use

Verifiability

Batch Testing & COA

Every production batch is sent for independent, third-party analysis at Janoshik Analytical. When results return, the full Certificate of Analysis for the exact batch you receive is published here and in our COA library, carrying its SHA-256 checksum and the lot number printed on your vial, so you can confirm the document is genuine and untampered. We publish every certificate, including any that fail.

How to verify a COA and its SHA-256 checksum →