English
EUR €
In stock
Selank
€29.95
ShippingTracked, dispatched to EU and non-EU
Buy 3, get 1 free on all peptides. The lowest-priced vial is free, applied in cart. Free shipping over €250.
Linear nonapeptide, sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
For laboratory research only. Not for human or animal use.
Testing information · Delivery · Returns
DSIP is a linear nonapeptide - nine amino acids joined end to end - with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, written WAGGDASGE in one-letter code. The molecular formula is C35H48N10O15 and the molecular weight is 848.8 g/mol. The chain carries no basic residues; the only ionisable side chains are the carboxylate of aspartate at position 5 and the carboxylate of glutamate at position 9, so the molecule sits at a net negative charge at physiological pH. Both termini are free - an unprotected N-terminal tryptophan and an unprotected C-terminal glutamic acid - with no amidation, acetylation or disulfide bridging; this is the structure recorded for PubChem CID 68816 and for UniProt P01158, the rabbit DSIP entry. The single tryptophan is the only aromatic residue in the sequence and therefore the only strong UV chromophore, which is what makes 280 nm quantitation practical.
All presented information is based on scientific publications which can be found at the end of product description below.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, ect.
Peptides in lyophilized form are supplied in glass vials by standard shipping methods and do not require refrigeration. Short-term temperature fluctuations during transport will not reduce their quality and efficacy. Even at high summer temperatures, the peptides in lyophilized form are stable for several weeks.
Upon receiving the lyophilized peptide, store at 4 °C or colder and away from bright light. Lyophilized peptides are stable at room temperature for weeks, but for longer-term storage, it is safer to store at -20 °C or colder. Exposure to moisture will greatly decrease long-term stability of lyophilized peptides. Before using the peptide, remove from cold storage and allow the peptide to equilibrate to room temperature before removing the lid of the container, in order to reduce the uptake of moisture that is present in the surrounding atmosphere.
The shelf life of peptide solutions is limited. Freezing the aliquots will prolong the storage life of the peptide. What is globally accepted for peptides in solution is that they are generally stable for 3 or more weeks at +4°C and for 3-4 months at -20°C. Avoid repeated freeze-thaw cycles, as this can degrade the peptides.
Used solely for in vitro experiments and cannot be:
DSIP stands for delta sleep-inducing peptide. It is a nine-residue peptide with the sequence WAGGDASGE, studied in sleep research. The name describes its research history; it does not establish an effect in people. This listing supplies a 5 mg lyophilised laboratory research vial. See the chemical identity and specification.
Results are mixed. A 1987 study in 14 people reported improved sleep and daytime performance. A 1992 double-blind study in 16 people found weak improvements in some objective sleep measures, no change in subjective sleep quality, and concluded that major short-term benefit for chronic insomnia was unlikely. These small studies do not establish efficacy or long-term safety for this catalogue vial.
No. The 5 mg label states the material mass in the vial. A solution concentration also requires its final volume. The laboratory concentration calculator explains that arithmetic; it does not select a dose or establish a research protocol. This material is for laboratory research only, not human or animal use.
No independent DSIP report is currently published in our certificate library. A stated purity target is a specification, not a measured result. Ask about product documentation if your laboratory requires an independent result before ordering.
Delivery depends on the destination. Check shipping times and charges before ordering; the order total and available payment methods appear at checkout.
Neutral reference material and handling tools from across the site. Research use only.
Compounds examined in neurological and behavioural models.
ReferenceWhat the 0.9% benzyl alcohol preservative does, the 28-day in-use window, and which vial size fits your work.
ToolWork out the exact bacteriostatic water to add and the volume to draw for a target research concentration.
DSIP is a linear nonapeptide - nine amino acids joined end to end - with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, written WAGGDASGE in one-letter code. The molecular formula is C35H48N10O15 and the molecular weight is 848.8 g/mol. The chain carries no basic residues; the only ionisable side chains are the carboxylate of aspartate at position 5 and the carboxylate of glutamate at position 9, so the molecule sits at a net negative charge at physiological pH. Both termini are free - an unprotected N-terminal tryptophan and an unprotected C-terminal glutamic acid - with no amidation, acetylation or disulfide bridging; this is the structure recorded for PubChem CID 68816 and for UniProt P01158, the rabbit DSIP entry. The single tryptophan is the only aromatic residue in the sequence and therefore the only strong UV chromophore, which is what makes 280 nm quantitation practical.
The name is historical rather than functional. Schoenenberger's 1984 review in European Neurology records that from 1963 to 1970 his group established humoral transmission of delta-wave (slow-wave sleep) EEG activity in rabbits by intracerebroventricular infusion of extracorporeal dialysate taken from the blood of donor animals kept asleep by electrical stimulation of the ventromedian intralaminar thalamus, and that from 1970 to 1977 the group isolated, characterised and synthesised the nonapeptide held responsible for that effect. Monnier and colleagues published the side-by-side comparison of the original isolate and the synthetic nonapeptide in Experientia in 1977. Kovalzon and Strekalova, writing in the Journal of Neurochemistry in 2006, date the isolation to 1977 and state that no DSIP gene, protein or related receptor has been isolated in the decades since, and that the DSIP structure is different from any other known representative of the various peptide families.
On stability, Schoenenberger reported in that same 1984 paper that the half-life for proteolytic split-off of tryptophan by brain slices and homogenates is 15 minutes, and that endogenous immunoreactive DSIP-like material in plasma, urine and cerebrospinal fluid was found bound to a larger protein and thereby protected from proteolysis. That 15-minute figure is an in vitro brain-tissue measurement, not a blood or plasma half-life; no plasma half-life appears on this page because none could be confirmed against primary literature. Material is supplied as a lyophilised powder specified at 99% or higher purity by HPLC.
DSIP is a nine-residue peptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE). This catalogue entry specifies a 5 mg vial for laboratory research. The references below document the published literature; they do not establish a result for the material supplied here.
€29.95
€29.95
€88.95
€101.95
€34.95
Before ordering, review how to assess peptide documentation and our laboratory research-use policy.
Reading in Spanish? See DSIP en España and the Spanish DSIP research guide.